Polly: An Ecosystem that Enables Cell Metabolism Labs

Discovery of a drug target requires expertise from different arms of a cell metabolism lab. A typical cell metabolism lab has a core biology facility that performs wet lab experiments, separate metabolomics and genomics core facilities, and a bioinformatics group to aid the core facilities. This is a case study of one such lab where … Continue reading Polly: An Ecosystem that Enables Cell Metabolism Labs

Story of a Gene: Making Sense of the Random Errors of Life

Introduction: In 1990, an ambitious project was launched in the USA to sequence the human DNA and identify, both functionally and structurally, genes that makeup the whole genome. It was called the Human Genome Project (HGP). A few years later, another ambitious project was launched to study the abnormal human DNA – The Cancer Genome … Continue reading Story of a Gene: Making Sense of the Random Errors of Life

From Fighter Planes to Omics: Why Iterate?

You may have probably read Boyd’s law of iteration[1].  If you haven’t, already, have a look at it. In Roger’s words[2]: “In analyzing complexity, fast iteration almost always produces better results than in-depth analysis.” This is especially true of exploratory work, where the goals are not well defined, and can possibly change with time. Boyd’s … Continue reading From Fighter Planes to Omics: Why Iterate?

Principal Component Analysis on Big data

Problem Statement Principal component analysis (PCA) is a fairly common statistical technique used to reduce the dimensions of data containing a large set of interrelated variables. Problems start to arise when the number of observations and variables are very large. At this point classical PCA techniques require sizeable memory and immense computational time. While working with … Continue reading Principal Component Analysis on Big data

Breaking the Stereotype of Gender Biasness in Indian Tech Startups

After the blog by Susan Fowler and Indian Fowler, various articles came up about the lax laws against harassment in Indian startups, ‘bro-culture’ in startups or perhaps tech community in general. These things are not new, workplace harassment is still not tackled very well in Indian corporates, the tech community was never women-friendly, and these … Continue reading Breaking the Stereotype of Gender Biasness in Indian Tech Startups